Upon injury or infection, prokaryotic and/or eukaryotic cells release plethora of disorganized denatured molecules into tissue microenvironment. Many of them are water-insoluble, that clog capillaries, incur damages of cellular membrane and disturb tissue homeostasis. The water-insoluble molecules in living organisms need to be removed as soon as they appear in tissues. If not, they cause deleterious inflammation.
In the beginning, life on earth was created in the water. The battle between water-soluble and insoluble substances began when the lives advanced to the land. Water-insoluble molecules are the origin of foe. The immune system has piggy-backed on the system devastating water-insoluble aggregates. We study immunology and inflammation, taking biological solubility at the center of intricate immunological balance.
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